Heparinase I rapidly and specifically neutralizes both unfractionated heparin as well as low molecular weight heparin, allowing baseline hemostasis to be monitored in the presence of these anticoagulants.

As a result, heparinase I is incorporated into disposables from a number of leading diagnostic companies, and is in development for additional diagnostic uses.

 

Heparinase Activated Clotting Time (ACT)
Heparinase ACT may be performed several times during CABG surgery to assess heparin reversal, hemodilution and heparin rebound.

 

Hepzyme
Hepzyme may be added to blood samples to reduce test ambiguity when the presence of heparin or low molecular weight heparin is suspected.

 

Heparinase Thromboestastograph (TEG)
Heparinase TEG may be performed several times during CABG surgery to assess heparin reversal, hemodilution heparin rebound, platelet function and fibrinolysis.

 

Heparinase Prothrombin Time (PT)
Heparinase is added to PT cartridges to make them heparin insensitive, for monitoring oral anticoagulation therapy.

 

Heparinase Rotation Thromboelastometry
Heparinase Rotation Thromboelastometry may be performed several times during CABG surgery to assess heparin reversal, hemodilution heparin rebound.

 

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