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References

Adams ME. (1994) Changes in aggrecan populations in experimental osteoarthritis. Osteoarthritis Cartilage 2: 155-64.

 

Alwan WH, Carter SD, Bennett D, Edwards GB. (1991) Glycosaminoglycans in horses with osteoarthritis. Equine Vet J 23: 44-7.

 

Andersson ML, Petersson IF, Karlsson KE, Jonsson EN, Mansson B, Heinegard D, Saxne T. (2006) Diurnal variation in serum levels of cartilage oligomeric matrix protein in patients with knee osteoarthritis or rheumatoid arthritis. Ann Rheum Dis 65: 1490-4.

 

Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, Poole RA, Aebi M, Alini M. (1996) The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. 15; 98(4):996-1003

 

Arican M, Carter SD, Bennett D, May C. (1994) Measurement of glycosaminoglycans and keratan sulphate in canine arthropathies . Res Vet Sci 56: 290-7.

 

Armstrong L, Thicket DR, Mansell JP, Ionescu M, Hoyle E, Billinghurst RC, Poole AR, Millar AB. (1999) Changes in collagen turnover in early acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 160: 1910-1915.

 

Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA. (2005) Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints . Arthritis Rheum. 52: 112-19

 

Belcher C, Yaqub R, Fawthrop F, Bayliss M, Doherty M. (1997) Synovial fluid chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in arthritic and normal knees. Ann Rheum Dis 56: 299-307.

 

Billinghurst C, Knowlton M, Brama P, van Weeren R McIIwraith W, (2003) Serum levels of collagen biomarkers reflect exercise-induced changes in cartilage. Trans ORS 28: 0764.

 

Billinghurst C, McGraw M, Brama P, van Weeren R, McIIwraith W. (2002) Alterations in serum levels of biomarkers of collagen metabolism in equine osteochondrosis. Trans ORS 27:0151.

 

Billinghurst RC, Dahlberg M, Ionescu M, Reiner A, Bourne C, Rorabeck P, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, Van Wart H, Poole AR. (1997) Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J. Clin. Invest. 99:1535-1545.

 

Billinghurst RC, Wu W, Ionescu M, Reiner A, Dahlberg L, Chen J, Van Wart H, Poole AR. (2000) Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilage induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase. Arthritis Rheum. 43: 664-672.

 

Cahue S, Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L, Poole AR. (2007) The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis. Osteoarthritis Cartilage 15: 819-23.

 

Carey DE, Alini M, Ionescu M, Hyams JS, Rowe JC, Rosenberg LC, Poole AR. (1997) Serum content of the C-propeptide of the cartilage molecule type II collagen in children. Clin Exp Rheumatol 15: 325-8.

 

Céleste C, Ionescu M, Robin Poole A, Laverty S. (2005) Repeated intraarticular injections of triamcinolone acetonide alter cartilage matrix metabolism measured by biomarkers in synovial fluid. J Orthop Res. 23: 602-10

 

Cerejo R, Poole AR, Ionescu M, Lobanok T, Song J, Cahue S, Dunlop D, Sharma L. (2003) The association between cartilage collagenase activity measured in serum and progression of knee osteoarthritis in patients with and without evidence of generalized disease. Trans. 66 th Mtg ACR.

 

Chang K, Cohn RG, Sun M, Fajardo LF, Zuo F, Eugui EM. (2003) Overexpression and catabolic activity of matralysin (MMP7) in OA cartilage. Inflamm. Res, Supl. 2, 52:S167.

 

Chu Q, Lopez M, Hayashi K, Ionescu M, Billinghurst RC, Johnson KA, Poole AR, Markel MD. (2002) Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of point instability in the dog . Osteoarthritis and Cartilage 10: 662-669.

 

Cibere J, Thorne A, Kopec JA, Singer J, Canvin J, Robinson DB, Pope J, Hong P, Grant E, Lobanok T, Ionescu M, Poole AR, Esdaile JM. (2005) Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkers. J Rheumatol 32: 896-902.

 

Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM. (2009) Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum. 60(5):1372-80

 

Conrozier T, Ferrand F, Poole AR, Verret C, Mathieu P, Ionescu M, Vincent F, Piperno M, Spiegel A, Vignon E. (2007) Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies. Osteoarthritis Cartilage 15: 462-7.

 

Dahlberg L, Billinghurst C, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, Van Wart H, Poole AR. (2000) Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloprotease 1). Arthritis. Rheum. 43: 673-682.

 

Dejica VM,Mort JS, Laverty S, Percival MD, Antoniou J, Zukor DJ, Poole AR. (2008) Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage. Am J Pathol 173: 161-69

 

Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ. (2003) Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation. Arthritis Rheum 48: 3085-95.

 

Frisbie DD, Al-Sobayil F, Billinghurst RC, McIlwraith CW. (2003) Serum markers differentiate exercise from pathology and correlate to clinical parameters of pain in an osteoarthritic model. Trans ORS 28:0751.

 

Frisbie DD, Ray CS, Ionescu M, Poole AR, Chapman PL, McIlwraith W. (1999). Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses. AJVR 60:305-309.

 

Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, Delmas PD. (2002) Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis. Arthritis Rheum 46: 2613-24.

 

Glant TT, Mikecz PJ, Roughley PJ, Buzas E, Poole AR. (1986) Age related changes in protein-related epitopes of human articular cartilage proteoglycans. Biochem J. 236: 71-75.

 

Hinek A, Poole AR. (1988) The influence of vitamin D metabolites on the calcification of cartilage matrix and the C-propeptide of type II collagen (chondrocalcin) . J.Bone Min.Res. 3:421-429.

 

Hollander A P, Heathfield T F, Webber C, Iwata Y, Bourne R, Rorabeck C, Poole A R. (1994) Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J Clin Invest 93: 1722-32

 

Huebner JL, Kraus VB. (2006) Assessment of the utility of biomarkers of osteoarthritis in the guinea pig. Osteoarthritis Cartilage 14:923-30

 

Jordan JM, Luta G, Stabler T, Renner JB, Dragomir AD, Vilim V, Hochberg MC, Helmick CG, Kraus VB. (2003) Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project. Arthritis Rheum 48: 675-81.

 

King KB, Lindsey CT, Dunn TC, Ries MD, Steinbach LS, Majumdar S. (2004) A study of the relationship between molecular biomarkers of joint degeneration and the magnetic resonance-measured characteristics of cartilage in 16 symptomatic knees. Magn Reson Imaging 22: 1117-23

 

Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR. (2005) Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage. Arthritis Rheum. 52: 128-35

 

Kobayashi T, Yoshihara Y, Samura A, Yamada H, Shinmei M, Roos H, Lohmander LS. (1997) Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritis. Ann Rheum Dis 56: 500-3.

 

Kojima T, Mwale F, Yasuda T, Girard C, Poole AR, Laverty S. (2001) Early degradation of type IX and type II collagens with onset of experimental inflammatory arthritis. Arthritis Rheum. 44:120-127.

 

Kong SY, Stabler TV, Criscione LG, Elliott AL, Jordan JM, Kraus VB. (2006) Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis. Arthritis Rheum 54: 2496-504.

 

Leff RL, Elias I, Ionescu M, Reiner A, Poole AR. (2003) Molecular changes in human osteoarthritis cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase Inhibitor. J. Rheumatol. 30:544-549.

 

Lohmander SL, Ionescu M, Jugessor H, Poole AR. (1999) Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis and Rheumatism 42:534-544.

 

Lohmander SL, Yoshihara Y, Roos H, Kobayashi T, Yamada H, Shinmei M. (1996) Procollagen II C-Propeptide in Joint fluid: Changes in concentration with age, time after knee injury and osteoarthritis. J. Rheumatol. 23: 1765-1769.

 

Lopez MJ, Chu Q, Bogdanske J, Markel MD. (2003) Synovial fluid levels of collagenase generated type II neoepitope and a proteoglycan epitope in synovial fluid from dysplastic canine coxofemoral joints from youth to maturity. Trans. 49 th Mtg ORS 0756

 

Maksymowych WP, Poole AR, Hiebert L, Webb A, Ionescu M, Lobanok T, King L, Davis JC Jr. (2005) Etanercept exerts beneficial effects on articular cartilage biomarkers of degradation and turnover in patients with ankylosing spondylitis. J Rheumatol 32: 1911-7

 

Mansson B, Carey D, Alini M, Ionescu M, Rosenburg LC, Poole AR, Heingard D, Saxne T. (1995) Cartilage and bone metabolism in rheumatoid arthritis. Amer. Soc. Clin. Invest. 95:1071-1077.

 

Matyas JR, Atley L, Ionescu M, Eyre DR, Poole AR. (2004) Analysis of cartilage biomarkers in early phase of canine experimental osteoarthritis. Arthritis Rheumatism 50; 543-552

 

Mazzuca SA, Poole AR, Brandt KD, Katz BP, Lane KA, Lobanok T. (2006) Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis. J Rheumatol 33: 1147-51.

 

Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C. (2003) Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis 62: 332-6.

 

Mullan RH, Matthews C, Bresnihan B, Fitzgerald O, King L, Poole AR, Fearon U, Veale DJ. (2007) Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy. Arthritis Rheum 56: 2919-2928.

 

Mwale F, Billinghurst C, Wu W, Alini M, Webber C, Reiner A, Ionescu M, Poole J, Poole A R. (2000) Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype . Developmental dynamics 218(4):648-62.

 

Neidhart M, Muller-Ladner U, Frey W, Bosserhoff AK, Colombani PC, Frey-Rindova P, Hummel KM, Gay RE, Hauselmann H, Gay S. (2000) Increased serum levels of non-collagenous matrix proteins (cartilage oligomeric matrix protein and melanoma inhibitory activity) in marathon runners. Osteoarthritis Cartilage 8: 222-9.

 

Nelson F, Billinghurst RC, Pidoux I, Reiner A, Langworthy M, McDermott M, Malogne T, Sitler DF, Kilambi NR, Lenczner E, Poole AR. (2006) Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament. Osteoarthritis Cartilage 14: 114-9

 

Nelson F, Dalhberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, Fraser GL, Brooks E, Tanzer M, Rosenberg LC, Dieppe P, Poole AR. (1998) Evidence for altered synthesis of type II collagen in patients with osteoarthritis. J. Clin. Invest. 102: 2115-2125.

 

Olsen AK, Sondergaard BC, Byrjalsen I, Tanko LB, Christiansen C, Muller A, Hein GE, Karsdal MA, Qvist P. (2007) Anabolic and catabolic function of chondrocyte ex vivo is reflected by the metabolic processing of type II collagen. Osteoarthritis Cartilage 15: 335-42.

 

Otterness IG, Swindell AC, Zimmerer RO, Poole AR, Ionescu M, Weiner E. (2001) An analysis of 14 molecular markers for monitoring osteoarthritis. Segregation of the markers into clusters and distinguishing osteoarthritis at baseline. Osteoarthritis and Cartilage. 9: 224-231.

 

Poole AR, Alini M, Hollander AH. (1995) Cellular biology of cartilage degradation. In: Henderson B, Edwards, J.C.W, Pettipher, E.R, (Eds.). Mechanisms and models in rheumatoid arthritis. London: Academic Press; pp. 163-204.

 

Poole AR, Ionescu M, Swan A, Dieppe PA. (1994) Changes in cartilage metabolism in arthritis reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan: implications for pathogenesis. J Clin Invest. 94:25-33.

 

Rizkalla G, Reiner A, Bogosh E, Poole AR. (1992) Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease. J. Clin Invest. 90: 2268-2277.

 

Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L, Cahue S, Poole AR.(2004) The Ratio of Collagen Breakdown to Collagen Synthesis and its Relationship with the Progression of Knee Osteoarthritis. Arthrtis Rheum. 50(9): S282.

 

Song X-Y, Zeng L, Jin W, Thompson J, Mizel DE, Lei KJ, Billinghurst RC, Poole AR, Wahl SM. (1999) Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis. J Exp. Med, 190: 535-542.

 

Spector TD, James IT, Hall GM, Thompson PW, Perrett D, Hart DJ. (1993) Increased levels of urinary collagen crosslinks in females with rheumatoid arthritis . Clin Rheumatol 12: 240-4.

 

Squires GR, Okouneff S, Ionescu M, Poole AR. (2003) The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis. Arthritis Rheum. 48: 1261-70

 

Sugiyama S, Itokazu M, Suzuki Y, Shimizu K. (2003) Procollagen II C propeptide level in the synovial fluid as a predictor of radiographic progression in early knee osteoarthritis. Ann Rheum Dis 62: 27-32.

 

Sukhova GK, Schönbeck Y, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P. (1999) Evidence for increased collagenolysis by interstitial collagenases -1 and -3 in vulnerable human atheromatous plaques. Circulation 99:2503-2509.

 

Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, Reiner A, Poole AR, Laverty S. (2005) Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis. Arthritis Rheum. 52: 1118-28

 

Trumble TN, Billinghurst RC, McIlwraith CW. (2003) Increased levels of synthesis and degradation markers of type II collagen in the synovial fluid of canine cruciate transaction model of osteoarthritis . Trans ORS 27:0679.

 

Verstappen SM, Poole AR, Ionescu M, King LE, Abrahamowicz M, Hofman DM, Bijlsma JW, Lafeber FP. (2006) Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis. Arthritis Res Ther 8: R31.

 

Visvanathan S, Smolen J, St. Clair EW, Marini JC, Pritchard C, Shergy WJ, Pendley C, Joshi S, Baker D, Wagner CL. (2004) Changes in Inflammatory Disease Markers and Associations with Clinical Efficacy Following Infliximab Plus Methotrexate Therapy in Patients with Early Rheumatoid Arthritis. Arthrtis Rheum. 50(9): S396

 

Yasuda T, Poole AR, Shimizu M, Yoshida M, Julovi SM, Hiramitsu T, Nakamura T. (2003) Involvement of CD44 in matrix metalloproteinase induction by COOH-terminal heparin-binding fibronectin fragment in human articular cartilage in culture. Inflamm. Res, Supl. 2, 52:S169.

 

Zack DJ, Bolon B, Hu Y-L, Poole AR, Feige U. (2003) Destruction of joint cartilage in rats with adjuvent-induced arthritis is reduced in an additive fashion by combination therapy with inhibitors of IL-1 and TNF. Arthritis and Rheumatism 48(S):S556